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JINGJIANG XU, SHAOZHEN SONG, WEI WEI, AND RUIKANG K. WANG*
University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA
Abstract: Wide-field vascular visualization in bulk tissue that is of uneven surface is challenging due to the relatively short ranging distance and significant sensitivity fall-off for most current optical coherence tomography angiography (OCTA) systems. We report a long ranging and ultra-wide-field OCTA (UW-OCTA) system based on an akinetic swept laser. The narrow instantaneous linewidth of the swept source with its high phase stability, combined with high-speed detection in the system enable us to achieve long ranging (up to 46 mm) and almost negligible system sensitivity fall-off. To illustrate these advantages, we compare the basic system performances between conventional spectral domain OCTA and UW-OCTA systems and their functional imaging of microvascular networks in living tissues. In addition, we show that the UW-OCTA is capable of different depth-ranging of cerebral blood flow within entire brain in mice, and providing unprecedented blood perfusion map of human finger in vivo. We believe that the UW-OCTA system has promises to augment the existing clinical practice and explore new biomedical applications for OCT imaging.
©2016 Optical Society of America.
OCIS codes: (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.0110) Imaging systems; (140.3600) Lasers, tunable; (170.2655) Functional monitoring and imaging.