Articoli Scientifici di Oftalmologia

Argomento : 2

Differences in Central Corneal Thickness between Spectral Domain-Optical Coherence Tomography and Ultrasound Pachymetry in Patients with Dry Eye Disease

Purpose. 
To compare central corneal thickness (CCT) values via Spectral Domain-Optical Coherence Tomography (SD-OCT) and ultrasonic pachymetry in patients with severe dry eye disease (DED) to determine the level of agreement between these 2 methods.

Methods.
The paired samples 𝑡-test asused to compare CT value sin severe DED patients. Matching analysis between methods was performed using intraclass correlation coefficient (ICC). 


Intrasession reliability of the measurement methods was calculated via the concordance correlation coefficient(CCC), variation equivalent, and Pearson’scor relation coefficient. The Bland Altman procedure was used tographically represent the differences between CCT values.

Results.
The study included 56 eye sof 24 female and 4 male patients. Mean age of the patient swas 50.9 ± 11.3 years. Mean CCT via CirrusSD-OCT was  523.82 ± 30.98 𝜇m versus 530.050 ± 31.85 𝜇m via ultrasonic pachymetry (paired samples 𝑡-test, 𝑃 < 0.001). The Bland-Altman plot showed good agreement between the examiners. The ICC for repeatability was 0.974. The CCC between the 2 methods ’CCT values was 0.973. The variation equivalent was 0.976 and Pearson’scor relation coefficient was 99.3%, which also indicated high correlation between the 2 methods’ measurements.

Conclusions. 
The present findings show that inpatient swith severe DED Cirrus SD-OCT provides reliable intraobserver CCT values.  
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